In this review, we discuss practical evaluation of beta-lactam allergy and cross-reactivity between penicillins and cephalosporins. However, screening patients without a prior history of beta-lactam allergy is routinely recommended. Historically, it has been reported that cephalosporins (of which cefazolin is a first-generation) have up to a 10 cross-reactivity with penicillin.
#Cross reactivity allergy skin#
Drug allergy work-ups that include standardized skin tests, reliable in vitro tests, and drug provocation tests are rarely carried out in clinical practice. Cross-reactivity in allergic reactions occurs when the proteins in one substance (typically pollen) are similar to the proteins found in another substance. Antibody cross-reactivity can, unfortunately, increase the number of allergens that an allergic person reacts to. Issues of cross-reactivity between cephalosporins, penicillins, and related drugs, and the subsequent use of cephalosporins and related antibiotics in patients with cephalosporin or penicillin allergy, are discussed. In cases of true penicillin allergy, the source of the reaction is thought to be due to formation of antibodies against metabolites of the penicillin molecule. Major and minor determinants of penicillin for skin testing are unavailable, making skin testing appear to be less sensitive. This topic reviews the clinical manifestations, pathogenesis, and diagnosis of hypersensitivity reactions to cephalosporins. In Korea, however, the diagnostic approach to beta-lactam allergy remains a major challenge. The diagnostic approach to beta-lactam allergy should be considered if the risk/possible benefit ratio is positive. A definitive diagnosis of beta-lactam hypersensitivity is required to carry out the proper preventive measures. These reactions can be broadly classified as immediate or non-immediate/delayed depending on the onset of the reaction after the last drug administration.
Sang-Hoon Kim, Tel: +82-, Fax: +82-, Email: and cephalosporins are commonly prescribed beta-lactam antibiotics that are able to induce severe and sometimes even life-threatening hypersensitivity reactions.
The Korean Journal of Medicine 2014 87(6):652-658.ĭepartment of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea
0 kommentar(er)
